UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for anxiety disorders in the United Kingdom. Explore treatment pathways including novel pharmacotherapy, psychotherapy, and neuromodulation.
Anxiety disorders affect over 8 million people in the UK, making them the most common mental health condition. Types include generalised anxiety disorder (GAD), social anxiety disorder, panic disorder, specific phobias, and agoraphobia. While normal anxiety is part of life, clinical anxiety is persistent, excessive, and significantly interferes with daily functioning. Many people wait years for diagnosis and treatment.
First-line treatment is typically CBT (cognitive behavioural therapy) through NHS Talking Therapies (IAPT). Medication options include SSRIs (sertraline, escitalopram), SNRIs (venlafaxine, duloxetine), and pregabalin. For treatment-resistant anxiety, options are more limited. Benzodiazepines are recommended only for short-term crisis use due to dependence risk.
Research is expanding rapidly: psilocybin-assisted therapy showing rapid anxiety reduction, MDMA-assisted therapy for social anxiety, ketamine/esketamine for treatment-resistant cases, digital therapeutics (app-based CBT, VR exposure therapy), transcranial magnetic stimulation (TMS), novel anxiolytics targeting neurosteroid pathways (zuranolone), and gut microbiome interventions for the gut-brain axis.
UK anxiety disorder trials are available through NHS mental health trusts, universities, and specialist research centres. Current studies include: novel pharmacotherapy, psychedelic-assisted therapy, digital interventions, neuromodulation, and combination approaches. Many trials accept participants who have not responded to standard treatment.
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