UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for hypertension in the United Kingdom. Explore treatment pathways including novel antihypertensives, renal denervation, and device-based therapies.
Hypertension affects over 1 in 3 adults in the UK (~14 million people) and is the single biggest risk factor for preventable death worldwide. It rarely causes symptoms, earning it the name "silent killer." Untreated, it significantly increases risk of stroke, heart attack, heart failure, kidney disease, and dementia. Blood pressure is classified as high when consistently above 140/90 mmHg (clinic) or 135/85 mmHg (home).
First-line medications include ACE inhibitors (ramipril), angiotensin receptor blockers (losartan), calcium channel blockers (amlodipine), and thiazide diuretics. Many patients need combination therapy. For resistant hypertension (uncontrolled on 3+ drugs including a diuretic), options include spironolactone, renal denervation, and baroreceptor activation therapy. NICE guidelines recommend stepwise treatment with regular monitoring.
Renal denervation (RDN) has emerged as a promising option for resistant hypertension, with catheter-based radiofrequency or ultrasound ablation of renal nerves. Endoscopic ultrasound-guided renal denervation is a newer approach. Other device therapies in trials include baroreceptor stimulation, central iliac arteriovenous fistula creation, and carotid body modulation. Novel drug targets include aldosterone synthase inhibitors and aminopeptidase A inhibitors.
UK hypertension trials are available through NHS cardiology and renal centres. Active areas: renal denervation long-term outcomes, novel antihypertensive agents, combination pill strategies, digital health interventions (remote monitoring, AI-guided treatment), lifestyle intervention trials, and hypertension in specific populations (pregnancy, elderly, chronic kidney disease).
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