UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for oesophageal (gullet) cancer in the United Kingdom. Explore treatment pathways including surgery, chemoradiation, and immunotherapy.
Oesophageal cancer affects ~9,100 people per year in the UK. The UK has one of the highest rates in Europe. There are two main types: adenocarcinoma (lower oesophagus, linked to acid reflux and Barrett's oesophagus) and squamous cell carcinoma (upper oesophagus, linked to smoking and alcohol). Survival has improved with multimodal treatment approaches.
Localised: neoadjuvant chemotherapy ± radiotherapy (FLOT regimen) followed by surgery. For adenocarcinoma with HER2 positivity, trastuzumab may be added. Locally advanced squamous: definitive chemoradiation. Metastatic: first-line chemotherapy (FOLFOX or paclitaxel + carboplatin) ± immunotherapy. For PD-L1 positive tumours, pembrolizumab or nivolumab may be used.
Active UK trials include: immunotherapy in the neoadjuvant setting, targeted therapy for HER2-positive disease, new chemotherapy combinations, minimally invasive surgical techniques, and screening approaches for Barrett's oesophagus (Cytosponge). The NHS is piloting a capsule sponge test for early detection.
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