UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for type 2 diabetes in the United Kingdom. Explore treatment pathways from lifestyle to advanced therapies.
Type 2 diabetes affects ~4.9 million people in the UK. It occurs when the body becomes resistant to insulin or doesn't produce enough. While traditionally considered progressive, recent research shows that remission is possible through significant weight loss. Newer medications (GLP-1 receptor agonists, SGLT2 inhibitors) have transformed management.
First-line: metformin + lifestyle changes. Second-line options are now guided by whether the patient has cardiovascular disease, kidney disease, or obesity. GLP-1 receptor agonists (semaglutide/Ozempic, tirzepatide/Mounjaro) for weight loss and cardiovascular benefit. SGLT2 inhibitors (dapagliflozin, empagliflozin) for heart failure and kidney protection.
The DiRECT trial showed that significant weight loss (15kg+) through intensive diet support can put type 2 diabetes into remission. This is now being offered through NHS England. Bariatric surgery also achieves remission in ~60-80% of patients. Clinical trials are exploring ways to make remission more achievable and sustainable.
Active UK diabetes trials include: next-generation GLP-1/GIP dual agonists, once-monthly insulin, closed-loop artificial pancreas systems, islet cell transplantation, stem cell-derived beta cells, and diabetes remission maintenance studies. The NHS Diabetes Prevention Programme is the largest in the world.
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