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The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

View on ClinicalTrials.gov ↗

At a glance

What the study gets you: Health checks and monitoring — no treatment given
Type of study: Observational (no treatment given)
Time in hospital: In-person visits at study sites — visit count not specified by the sponsor
Drug or intervention: Molecular Analyses (genetic)
How long the study runs: Study runs about 67 months (dates as stated)
About the drug or intervention: Molecular Analyses — genetic: Nucleic acid extraction, protein analysis.
Patient visit burden: Not specified by the sponsor

Type of study: Observing health over time
Ages: 18 Years and over
Who: All
Number of participants: 400
Started: 2023-09-08
Last checked: 2026-02

Plain English Summary

What is this study?

• Testing a new treatment for head and neck cancer
• Clinical study - 400 participants
• The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC)

Who can take part?

• Ages 18 Years and over
• Diagnosed with head and neck cancer

Where?

• Derby - University Hospitals Derby and Burton
• Edinburgh - NHS Lothian
• Glasgow - Western General, Greater Glasgow and Clyde
• Liverpool - Aintree Hospital
• +5 more UK sites

This is a simplified summary. Always discuss with your doctor before making any decisions.

About This Trial

More detail

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC). Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer. The aim of this study is to determine the survival, functional and quality of life outcomes of patients undergoing all salvage surgery for recurrent, residual and new primary head and neck SCC, and to establish the genetic architecture and clonal evolution H\&N SCC after previous treatment for radiotherapy cancer.

Head and Neck Cancer

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What we know so far

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Preliminary match based on your answers. Full eligibility requires on-site assessment including medical history, physical exam, and lab tests. This does not guarantee enrolment.

Eligibility at a Glance

Key info

Age: 18 Years and over
Who can join: All genders

What the study is looking for

✓Aged over 18
✓Previous H\&N SCC treated with radiotherapy with or without drug treatment
✓Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx
✓Ability to give agreement to take part for biological sample collection (molecular analysis study only)

Who cannot take part

✗Nasopharyngeal and cutaneous SCC of the H\&N
✗Thyroid, salivary gland, and non-squamous cell H\&N cancers
✗Presence of distant metastasis (M1) or surgically inoperable T4b tumours

See the full criteria

Inclusion Criteria: 1. Aged over 18 2. Previous H\&N SCC treated with radiotherapy with or without chemotherapy 3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oral cavity, larynx, and hypopharynx 4. Ability to give informed consent for biological sample collection (molecular analysis study only) Exclusion Criteria: 1. Nasopharyngeal and cutaneous SCC of the H\&N 2. Thyroid, salivary gland, and non-squamous cell H\&N cancers 3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours