UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for cervical cancer in the United Kingdom. Explore treatment pathways from early stage to advanced disease.
Cervical cancer affects ~3,200 women per year in the UK. Almost all cases are caused by HPV (human papillomavirus) infection. The NHS HPV vaccination programme (offered to girls and boys aged 12-13) is expected to dramatically reduce cervical cancer rates in coming decades. Regular cervical screening (smear tests) detects pre-cancerous changes early.
Early stage: surgery (hysterectomy or trachelectomy for fertility preservation). Locally advanced: chemoradiation (cisplatin + external beam radiotherapy + brachytherapy) is the standard treatment. Metastatic or recurrent: first-line pembrolizumab + chemotherapy (now standard based on KEYNOTE-826 trial), with bevacizumab for eligible patients. Second-line options include tisotumab vedotin (antibody-drug conjugate targeting tissue factor).
Active UK trials include: therapeutic HPV vaccines, new immunotherapy combinations, ADCs (antibody-drug conjugates), and novel radiotherapy techniques. The NHS cervical screening programme is exploring AI-assisted screening and HPV self-sampling. Trials also focus on quality of life and fertility preservation.
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