UK clinical trials - updated daily from ClinicalTrials.gov
Find clinical trials for endometriosis in the United Kingdom. Explore treatment pathways including hormonal therapy, pain management, and surgical options.
Endometriosis affects ~1.5 million women in the UK (~1 in 10). It occurs when tissue similar to the uterine lining (endometrium) grows outside the uterus, causing chronic pelvic pain, painful periods, pain during intercourse, and infertility. Diagnosis takes an average of 8 years in the UK - one of the longest diagnostic delays of any condition. It is a chronic, progressive condition with no known cure, but trials are exploring new diagnostic and treatment approaches.
First-line: pain management with NSAIDs and hormonal contraceptives (combined pill, progestogen-only pill, Mirena IUS). Second-line: GnRH agonists (leuprorelin, goserelin) or GnRH antagonists (elagolix, relugolix) which suppress ovarian hormone production. Surgical: laparoscopic excision of endometriosis lesions - considered gold standard but has recurrence rates of ~20-40% within 5 years. Fertility: IVF often needed but success rates are lower in endometriosis patients.
Endometriosis research is rapidly evolving. New oral GnRH antagonists (linzagolix approved in Europe) offer effective hormone suppression without the initial flare of GnRH agonists. Anti-inflammatory agents targeting the prostaglandin pathway and aromatase inhibitors show promise. Immunomodulators, including TNF-alpha inhibitors and anti-angiogenic agents, are being explored. Non-hormonal treatments are urgently needed for women trying to conceive.
Active UK endometriosis trials include: novel oral hormonal therapies (next-generation GnRH antagonists), non-hormonal pain treatments (TPGAT inhibitors, cannabinoids), AI-assisted laparoscopic diagnosis, endometrial ablation techniques, stem cell therapy for fertility preservation, and diagnostic biomarkers (saliva, blood, and endometrial tests). The UK's Endometriosis Research Network and Wellbeing of Women fund major trial initiatives.
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